Oncology/Hematology > > Other Cancers– Meta-analysis reveals inverted dose-response relationship for both drinks
by Charles Bankhead, Senior Editor, MedPage Today December 23, 2024
In the current analytical salvo of a continuous argument, individuals who took in more than 4 cups of caffeinated coffee daily had a lower danger of head and neck cancer (HNC), according to a meta-analysis of 14 released research studies.
The relative danger of any HNC decreased by 17%, consisting of statistically considerable decreases in the danger of mouth (30%) and oropharyngeal cancers (22%). Individuals who reported drinking 3 to 4 cups of coffee daily had a 41% lower danger of hypopharyngeal cancer. Consuming decaffeinated coffee and drinking more than absolutely no however less than one cup everyday were related to 25% and 34% decreases in the threat of mouth cancer, according to Yuan-Chin Amy Lee, PhD, of the University of Utah and Huntsman Cancer Institute in Salt Lake City, and associates.
Tea intake likewise declared a number of areas in the information, including a 29% decrease in the danger of hypopharyngeal cancer and a 9% decrease in the threat of any HNC cancer in association with more than absolutely no however no greater than one cup. Consuming more than one cup of tea everyday improved the threat of laryngeal cancer by 38%, as reported in Cancer
The information on relationships in between coffee and tea usage with particular kinds of HNC identified the analysis from previous work, according to Lee.
“The primary distinction from previous research studies is that we had the ability to have a big adequate research study population to take a look at oropharyngeal and hypopharyngeal independently,” stated Lee. “In addition, I think tea drinking was likewise not examined to take a look at oropharyngeal and hypopharyngeal individually. With these outcomes we specified the protective association with coffee drinking, both routine coffee and decaffeinated coffee.”
Worth of Observational Studies
Research studies such as this one represent a required initial step towards comprehending the relationship in between coffee and cancer, stated Jian-Min Yuan, MD, PhD, of the University of Pittsburgh and Hillman Cancer Institute.
“A bigger scale or speculative research study can verify the outcomes,” Yuan informed MedPage Today“We see something and after that establish speculative research studies or animal designs. This is a common research study for [the research process]”
Furthermore, a meta-analysis provides a way to get rid of the restrictions of little sample size and lower the disparities amongst the specific research studies.
The research studies consisted of in the meta-analysis were observational, and the biological system for the relationship in between coffee and cancer is unclear, he continued. The observational information enable scientists to establish and check out hypotheses.
“You need to [observe] something before you can do anything else,” stated Yuan. “That is what makes these research studies essential. They offer background that's valuable for future research studies.”
“At the end of the day, if we genuinely think there is some sort of real security [from coffee consumption]
